Publications
Select Publications: Present – 2010
Long noncoding RNA CHROMR Regulates Antiviral Immunity in Humans
van Solingen C, Cyr Y, Scacalossi KR, de Vries M, Barrett TJ, de Jong A, Gourvest M, Zhang T, Peled D, Kher R, Cornwell M, Gildea MA, Brown EJ, Fanucchi S, Mhlanga MM, Berger JS, Dittmann M and Moore KJ. Proc Natl Acad Sci USA. 2022
High-Throughput Screening Identifies MicroRNAs Regulating Human PCSK9 and Hepatic Low-Density Lipoprotein Receptor Expression
van Solingen C, Oldebeken SR, Salerno AG, Wanschel A and Moore KJ. Front Cardiovasc Med. 2021
Silencing Myeloid Netrin-1 Induces Inflammation Resolution and Plaque Regression
Schlegel M, Sharma M, Brown EJ, Newman AAC, Cyr Y, Afonso MS, Corr EM, Koelwyn GJ, van Solingen C, Guzman J, Farhat R, Nikain CA, Shanley LC, Peled D, Schmidt AM, Fisher EA and Moore KJ. Circ Res. 2021
Chronic stress primes innate immune responses in mice and humans
Barrett TJ, Corr EM, van Solingen C, Schlamp F, Brown EJ, Koelwyn GJ, Lee AH, Shanley LC, Spruill TM, Bozal F, de Jong A, Newman AAC, Drenkova K, Silvestro M, Ramkhelawon B, Reynolds HR, Hochman JS, Nahrendorf M, Swirski FK, Fisher EA, Berger JS and Moore KJ. Cell Rep. 2021
miR-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques
Afonso MS, Sharma M, Schlegel M, van Solingen C, Koelwyn GJ, Shanley LC, Beckett L, Peled D, Rahman K, Giannarelli C, Li H, Brown EJ, Khodadadi-Jamayran A, Fisher EA and Moore KJ. Circ Res. 2021
Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression
Sharma M, Schlegel MP, Afonso MS, Brown EJ, Rahman K, Weinstock A, Sansbury BE, Corr EM, van Solingen C, Koelwyn GJ, Shanley LC, Beckett L, Peled D, Lafaille JJ, Spite M, Loke P, Fisher EA and Moore KJ. Circ Res. 2020
Myocardial infarction accelerates breast cancer via innate immune reprogramming
Koelwyn GJ, Newman AAC, Afonso MS, van Solingen C, Corr EM, Brown EJ, Albers KB, Yamaguchi N, Narke D, Schlegel M, Sharma M, Shanley LC, Barrett TJ, Rahman K, Mezzano V, Fisher EA, Park DS, Newman JD, Quail DF, Nelson ER, Caan BJ, Jones LW and Moore KJ. Nat Med. 2020
The long noncoding RNA CHROME regulates cholesterol homeostasis in primate
Hennessy EJ, van Solingen C, Scacalossi KR, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, Caffrey BE, Hussein MA, Ricci EP, Temel RE, Garabedian MJ, Berger JS, Vickers KC, Kanke M, Sethupathy P, Teupser D, Holdt LM and Moore KJ. Nat Metab. 2019
Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism
Ouimet M, Koster S, Sakowski E, Ramkhelawon B, van Solingen C, Oldebeken S, Karunakaran D, Portal-Celhay C, Sheedy FJ, Ray TD, Cecchini K, Zamore PD, Rayner KJ, Marcel YL, Philips JA and Moore KJ. Nat Immunol. 2016
MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis
Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P and Moore KJ. J Clin Invest. 2015
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity
Ramkhelawon B, Hennessy EJ, Menager M, Ray TD, Sheedy FJ, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner KJ and Moore KJ. Nat Med. 2014
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT, Stuart LM, Latz E, Fitzgerald KA and Moore KJ. Nat Immunol. 2013
The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques
van Gils JM, Derby MC, Fernandes LR, Ramkhelawon B, Ray TD, Rayner KJ, Parathath S, Distel E, Feig JL, Alvarez-Leite JI, Rayner AJ, McDonald TO, O'Brien KD, Stuart LM, Fisher EA, Lacy-Hulbert A and Moore KJ. Nat Immunol. 2012
Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis
Rayner KJ, Sheedy FJ, Esau CC, Hussain FN, Temel RE, Parathath S, van Gils JM, Rayner AJ, Chang AN, Suarez Y, Fernandez-Hernando C, Fisher EA and Moore KJ. J Clin Invest. 2011
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA, Lacy-Hulbert A, El Khoury J, Golenbock DT and Moore KJ. Nat Immunol. 2010
MiR-33 contributes to the regulation of cholesterol homeostasis
Rayner KJ, Suarez Y, Davalos A, Parathath S, Fitzgerald ML, Tamehiro N, Fisher EA, Moore KJ and Fernandez-Hernando C. Science. 2010